|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:RB1_protein
gptkb:RB_protein
|
|
gptkbp:category
|
tumor suppressor
cell cycle regulator
|
|
gptkbp:decommissioned
|
gptkb:Adenovirus_E1A_protein
gptkb:HPV_E7_protein
gptkb:SV40_large_T_antigen
viral oncoproteins
|
|
gptkbp:degradedBy
|
gptkb:proteasome
|
|
gptkbp:discoveredBy
|
gptkb:Weinberg_lab
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:RB1_gene
|
|
gptkbp:expressedIn
|
most human tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Retinoblastoma_protein
|
|
gptkbp:function
|
tumor suppressor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
pRb
|
|
gptkbp:inhibitedBy
|
gptkb:E2F_transcription_factors
|
|
gptkbp:interactsWith
|
gptkb:p16INK4a
gptkb:MDM2
gptkb:Cyclin_D1
gptkb:E2F1
gptkb:HDAC1
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_13q14
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
osteosarcoma
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
1AD6
|
|
gptkbp:phosphorylates
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
cell cycle
|
|
gptkbp:requires
|
embryonic development
neuronal differentiation
cell cycle exit
muscle differentiation
|
|
gptkbp:role
|
apoptosis
differentiation
cellular senescence
DNA damage response
G1/S cell cycle checkpoint
|
|
gptkbp:UniProtID
|
P06400
|
|
gptkbp:bfsParent
|
gptkb:RB1
|
|
gptkbp:bfsLayer
|
6
|