|
gptkbp:instanceOf
|
gptkb:protein
tumor suppressor
|
|
gptkbp:alias
|
gptkb:retinoblastoma_susceptibility_protein
gptkb:RB1_protein
gptkb:pRb
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
gptkb:E2F_transcription_factors
|
|
gptkbp:conservedIn
|
vertebrates
|
|
gptkbp:decommissioned
|
phosphorylation
viral oncoproteins
|
|
gptkbp:dephosphorylatedBy
|
gptkb:protein_phosphatase_1
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:RB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:RB1
|
|
gptkbp:fullName
|
gptkb:Retinoblastoma_protein
|
|
gptkbp:function
|
regulation of cell cycle
control of G1/S transition
inhibition of cell proliferation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RB protein
|
|
gptkbp:interactsWith
|
gptkb:HPV_E7_protein
gptkb:SV40_large_T_antigen
gptkb:adenovirus_E1A_protein
|
|
gptkbp:locatedOnChromosome
|
gptkb:13q14
|
|
gptkbp:location
|
gptkb:nucleus
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma
prostate cancer
bladder cancer
osteosarcoma
|
|
gptkbp:OMIM
|
614041
|
|
gptkbp:PDB
|
gptkb:1GUX
|
|
gptkbp:phosphorylates
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:regulates
|
apoptosis
differentiation
cell cycle progression
DNA replication
|
|
gptkbp:requires
|
tumor suppression
cell cycle arrest
|
|
gptkbp:UniProtID
|
P06400
|
|
gptkbp:bfsParent
|
gptkb:pRb
gptkb:retinoblastoma-associated_protein
gptkb:retinoblastoma_protein
|
|
gptkbp:bfsLayer
|
7
|