|
gptkbp:instanceOf
|
gptkb:virus
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:contains
|
zinc finger motif
|
|
gptkbp:degradedBy
|
pRb protein
|
|
gptkbp:encodedBy
|
gptkb:HPV_E7_gene
|
|
gptkbp:firstDescribed
|
1989
|
|
gptkbp:foundIn
|
gptkb:human_papillomavirus
|
|
gptkbp:function
|
oncoprotein
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HPV E7 protein
|
|
gptkbp:inducedBy
|
cellular proliferation
|
|
gptkbp:inhibitedBy
|
tumor suppressor proteins
|
|
gptkbp:interactsWith
|
gptkb:retinoblastoma_protein
|
|
gptkbp:involves
|
malignant transformation
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~11 kDa
|
|
gptkbp:orthologIn
|
gptkb:SV40_large_T_antigen
gptkb:adenovirus_E1A_protein
|
|
gptkbp:phosphorylates
|
cellular kinases
|
|
gptkbp:presentIn
|
gptkb:HPV_type_16
gptkb:HPV_type_18
gptkb:HPV_type_31
gptkb:HPV_type_33
gptkb:HPV_type_45
gptkb:HPV_type_52
gptkb:HPV_type_58
|
|
gptkbp:recognizedBy
|
cytotoxic T lymphocytes
|
|
gptkbp:role
|
cell cycle regulation
|
|
gptkbp:sequence
|
98 amino acids (HPV16 E7)
|
|
gptkbp:target
|
therapeutic vaccines
|
|
gptkbp:usedIn
|
HPV diagnostic assays
|
|
gptkbp:bfsParent
|
gptkb:pRb
gptkb:retinoblastoma-associated_protein
|
|
gptkbp:bfsLayer
|
7
|