|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:Retinoblastoma_protein
|
|
gptkbp:discoveredBy
|
gptkb:Alfred_G._Knudson
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodedBy
|
gptkb:RB1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:RB1
|
|
gptkbp:function
|
tumor suppressor
regulation of cell cycle
|
|
gptkbp:HGNC_ID
|
9884
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RB1 protein
|
|
gptkbp:inhibitedBy
|
gptkb:E2F_transcription_factors
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_D
gptkb:p16INK4a
gptkb:MDM2
gptkb:E2F1
gptkb:HDAC1
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
13q14.2
|
|
gptkbp:molecularWeight
|
~110 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:retinoblastoma
prostate cancer
bladder cancer
Small Cell Lung Cancer
osteosarcoma
|
|
gptkbp:OMIM
|
614041
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1GUX
|
|
gptkbp:phosphorylates
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
inactive
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:G1/S_transition
apoptosis
cell proliferation
differentiation
senescence
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
pocket domain
|
|
gptkbp:UniProtID
|
P06400
|
|
gptkbp:unphosphorylatedForm
|
active
|
|
gptkbp:bfsParent
|
gptkb:pRb
|
|
gptkbp:bfsLayer
|
7
|