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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
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gptkb:CDKN2A_protein
gptkb:p16
gptkb:CDK4I
gptkb:INK4A
gptkb:MTS1
gptkb:cyclin-dependent_kinase_inhibitor_2A
|
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gptkbp:encodedBy
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gptkb:CDKN2A_gene
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gptkbp:Entrez_Gene_ID
|
1029
|
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gptkbp:expressedIn
|
various human tissues
|
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gptkbp:function
|
cyclin-dependent kinase inhibitor
|
|
gptkbp:HGNC_ID
|
HGNC:1787
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p16INK4a
|
|
gptkbp:inhibitedBy
|
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:involvedIn
|
cell cycle regulation
tumor suppression
|
|
gptkbp:length
|
156 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_9p21
|
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gptkbp:molecularWeight
|
16 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:glioblastoma
gptkb:familial_atypical_multiple_mole_melanoma_syndrome
melanoma
pancreatic cancer
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn2a
|
|
gptkbp:overexpressedIn
|
cellular senescence
|
|
gptkbp:prevention
|
phosphorylation of retinoblastoma protein (pRb)
|
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gptkbp:regulates
|
G1 phase of cell cycle
|
|
gptkbp:structure
|
contains ankyrin repeats
|
|
gptkbp:UniProtID
|
gptkb:P42771
|
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gptkbp:bfsParent
|
gptkb:CDKN2A
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gptkbp:bfsLayer
|
6
|