Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:virus
|
| gptkbp:alternativeSplicing |
produces multiple isoforms
|
| gptkbp:amendedBy |
chromatin structure
host cell transcription |
| gptkbp:encodedBy |
gptkb:Adenovirus_E1A_gene
|
| gptkbp:firstDescribed |
1978
|
| gptkbp:foundIn |
gptkb:Adenovirus
|
| gptkbp:function |
transcriptional regulator
oncoprotein |
| https://www.w3.org/2000/01/rdf-schema#label |
Adenovirus E1A protein
|
| gptkbp:inhibitedBy |
host cell antiviral response
|
| gptkbp:interactsWith |
gptkb:Rb_protein
gptkb:CBP gptkb:p300 |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:molecularWeight |
~289 amino acids (major isoform)
|
| gptkbp:requires |
Adenovirus early gene expression
|
| gptkbp:role |
cell cycle regulation
transcriptional activation apoptosis induction transformation of host cells |
| gptkbp:bfsParent |
gptkb:pRb
|
| gptkbp:bfsLayer |
7
|