Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:pRb
|
| gptkbp:discoveredBy |
gptkb:Weinberg_laboratory
|
| gptkbp:encodedBy |
gptkb:RB1_gene
|
| gptkbp:function |
tumor suppressor
regulation of cell cycle |
| https://www.w3.org/2000/01/rdf-schema#label |
Retinoblastoma protein
|
| gptkbp:inhibitedBy |
gptkb:E2F_transcription_factors
|
| gptkbp:interactsWith |
gptkb:BRG1
gptkb:MDM2 gptkb:Cyclin_D1 gptkb:HDAC1 |
| gptkbp:locatedOnChromosome |
13q14.2
|
| gptkbp:location |
gptkb:nucleus
|
| gptkbp:molecularWeight |
~110 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:small_cell_lung_carcinoma
gptkb:retinoblastoma osteosarcoma |
| gptkbp:phosphorylates |
gptkb:cyclin-dependent_kinases
releases E2F |
| gptkbp:postTranslationalModification |
phosphorylation
ubiquitination acetylation |
| gptkbp:role |
apoptosis
differentiation cellular senescence G1/S cell cycle checkpoint |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:UniProtID |
P06400
|
| gptkbp:unphosphorylatedForm |
binds E2F
|
| gptkbp:bfsParent |
gptkb:pRb
|
| gptkbp:bfsLayer |
7
|