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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
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gptkbp:alias
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gptkb:CDKN4
gptkb:KIP1
gptkb:p27Kip1
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gptkbp:associatedWith
|
tumor suppression
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gptkbp:degradedBy
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gptkb:ubiquitin-proteasome_pathway
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gptkbp:discoveredBy
|
James M. Roberts
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gptkbp:encodedBy
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gptkb:CDKN1B_gene
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gptkbp:expressionAlteredIn
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gptkb:neuroblastoma
gptkb:Wilms_tumor
gptkb:nasopharyngeal_carcinoma
gptkb:pineoblastoma
gptkb:cancer
gptkb:medulloblastoma
gptkb:endometrial_cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
gptkb:retinoblastoma
gptkb:pheochromocytoma
gptkb:Ewing_sarcoma
gptkb:schwannoma
gptkb:anaplastic_astrocytoma
gptkb:pilocytic_astrocytoma
gptkb:subependymal_giant_cell_astrocytoma
colorectal cancer
esophageal cancer
leukemia
liver cancer
melanoma
mesothelioma
pancreatic cancer
prostate cancer
testicular cancer
oral cancer
bladder cancer
adrenocortical carcinoma
head and neck cancer
salivary gland cancer
osteosarcoma
hepatocellular carcinoma
gastric cancer
glioma
pituitary adenoma
renal cell carcinoma
malignant peripheral nerve sheath tumor
ependymoma
oligodendroglioma
craniopharyngioma
meningioma
diffuse intrinsic pontine glioma
atypical teratoid/rhabdoid tumor
fibrosarcoma
germ cell tumor
ganglioglioma
pleomorphic xanthoastrocytoma
central neurocytoma
choroid plexus carcinoma
dysembryoplastic neuroepithelial tumor
medulloepithelioma
optic pathway glioma
parathyroid carcinoma
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gptkbp:function
|
cell cycle inhibitor
cyclin-dependent kinase inhibitor
|
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gptkbp:HGNC_ID
|
HGNC:1785
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p27 (CDKN1B)
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gptkbp:inhibitedBy
|
gptkb:CDK2
gptkb:CDK4
cyclin D-CDK4 complex
cyclin E-CDK2 complex
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:cyclin_D
gptkb:CDK2
gptkb:CDK4
gptkb:SKP2
gptkb:cyclin_E
|
|
gptkbp:length
|
198 amino acids
|
|
gptkbp:locatedIn
|
gptkb:nucleus
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|
gptkbp:locatedOnChromosome
|
12p13.1
|
|
gptkbp:molecularWeight
|
22 kDa
|
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gptkbp:mutationAssociatedWith
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gptkb:multiple_endocrine_neoplasia_type_4
|
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gptkbp:orthologIn
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gptkb:mouse
right
|
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gptkbp:phosphorylates
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gptkb:AKT1
gptkb:CDK2
|
|
gptkbp:regulates
|
G1 phase of cell cycle
transcriptional
proteolytic degradation
post-translational
|
|
gptkbp:UniProtID
|
P46527
|
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gptkbp:bfsParent
|
gptkb:P34130
|
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gptkbp:bfsLayer
|
8
|