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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
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gptkbp:alias
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gptkb:CDKN4
gptkb:KIP1
gptkb:p27Kip1
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gptkbp:associatedWith
|
tumor suppression
|
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gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
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gptkbp:discoveredBy
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James M. Roberts
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gptkbp:encodedBy
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gptkb:CDKN1B_gene
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gptkbp:expressionAlteredIn
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gptkb:neuroblastoma
gptkb:Wilms_tumor
gptkb:nasopharyngeal_carcinoma
gptkb:leukemia
gptkb:pineoblastoma
gptkb:cancer
gptkb:medulloblastoma
gptkb:germ_cell_tumor
gptkb:renal_cell_carcinoma
gptkb:bladder_cancer
gptkb:endometrial_cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
gptkb:retinoblastoma
gptkb:pheochromocytoma
gptkb:Ewing_sarcoma
gptkb:schwannoma
gptkb:anaplastic_astrocytoma
gptkb:glioma
gptkb:pilocytic_astrocytoma
gptkb:testicular_cancer
gptkb:pituitary_adenoma
gptkb:subependymal_giant_cell_astrocytoma
gptkb:melanoma
gptkb:oral_cancer
gptkb:oligodendroglioma
colorectal cancer
esophageal cancer
liver cancer
mesothelioma
pancreatic cancer
prostate cancer
adrenocortical carcinoma
head and neck cancer
salivary gland cancer
osteosarcoma
hepatocellular carcinoma
gastric cancer
malignant peripheral nerve sheath tumor
ependymoma
craniopharyngioma
meningioma
diffuse intrinsic pontine glioma
atypical teratoid/rhabdoid tumor
fibrosarcoma
ganglioglioma
pleomorphic xanthoastrocytoma
central neurocytoma
choroid plexus carcinoma
dysembryoplastic neuroepithelial tumor
medulloepithelioma
optic pathway glioma
parathyroid carcinoma
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gptkbp:function
|
gptkb:cyclin-dependent_kinase_inhibitor
cell cycle inhibitor
|
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gptkbp:HGNC_ID
|
HGNC:1785
|
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gptkbp:inhibitedBy
|
gptkb:CDK2
gptkb:CDK4
cyclin D-CDK4 complex
cyclin E-CDK2 complex
|
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gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:cyclin_D
gptkb:CDK2
gptkb:CDK4
gptkb:SKP2
gptkb:cyclin_E
|
|
gptkbp:length
|
198 amino acids
|
|
gptkbp:locatedIn
|
gptkb:nucleus
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gptkbp:locatedOnChromosome
|
12p13.1
|
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gptkbp:molecularWeight
|
22 kDa
|
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gptkbp:mutationAssociatedWith
|
gptkb:multiple_endocrine_neoplasia_type_4
|
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gptkbp:orthologIn
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gptkb:mouse
gptkb:right
|
|
gptkbp:phosphorylates
|
gptkb:AKT1
gptkb:CDK2
|
|
gptkbp:regulates
|
G1 phase of cell cycle
transcriptional
proteolytic degradation
post-translational
|
|
gptkbp:UniProtID
|
P46527
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gptkbp:bfsParent
|
gptkb:P34130
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gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p27 (CDKN1B)
|