|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
F-box/LRR-repeat protein 1
FBXL1
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:component
|
SCF complex
|
|
gptkbp:discoveredBy
|
Zhong et al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodedBy
|
SKP2 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:6502
gptkb:SKP2
ENSG00000145604
|
|
gptkbp:expressedIn
|
high in proliferating cells
low in quiescent cells
|
|
gptkbp:fullName
|
S-phase kinase-associated protein 2
|
|
gptkbp:function
|
cell cycle regulation
E3 ubiquitin ligase component
|
|
gptkbp:gene
|
gptkb:SKP2
|
|
gptkbp:HGNC_ID
|
10901
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SKP2
|
|
gptkbp:inhibitedBy
|
C1 (small molecule inhibitor)
SZL-P1-41
|
|
gptkbp:interactsWith
|
gptkb:RB1
CUL1
CDKN1A (p21Cip1)
CDKN1B (p27Kip1)
SKP1
|
|
gptkbp:involvedIn
|
gptkb:G1/S_transition_of_cell_cycle
ubiquitin-mediated proteolysis
|
|
gptkbp:locatedOnChromosome
|
5p13
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:OMIM
|
604089
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:overexpressedIn
|
linked to tumorigenesis
|
|
gptkbp:PDB
|
2ASS
2AST
|
|
gptkbp:phosphorylates
|
Ser72
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell proliferation
p27Kip1 degradation
|
|
gptkbp:significance
|
potential cancer therapy target
|
|
gptkbp:structure
|
contains F-box domain
contains leucine-rich repeats
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:target
|
gptkb:miR-145
miR-342
|
|
gptkbp:UniProtID
|
Q13309
|
|
gptkbp:bfsParent
|
gptkb:CDKN1B
gptkb:SCF(SKP2)_complex
|
|
gptkbp:bfsLayer
|
7
|