|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CDKN1B
Cyclin-dependent kinase inhibitor 1B
|
|
gptkbp:associatedWith
|
cancer progression
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
SCF(Skp2) complex
|
|
gptkbp:discoveredBy
|
gptkb:Polyak_et_al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:downregulatedIn
|
various cancers
|
|
gptkbp:encodedBy
|
gptkb:CDKN1B_gene
|
|
gptkbp:function
|
cyclin-dependent kinase inhibitor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p27Kip1
|
|
gptkbp:inhibitedBy
|
gptkb:CDK2
gptkb:CDK4
gptkb:CDK6
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:cyclin_A
gptkb:cyclin_E
CDK2-cyclin complexes
Skp2
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13
|
|
gptkbp:molecularWeight
|
27 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:multiple_endocrine_neoplasia_type_4
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1b
|
|
gptkbp:phosphorylates
|
Thr187
Ser10
Thr198
|
|
gptkbp:regulates
|
gptkb:TGF-beta
growth factors
cell cycle
S phase entry
G1 phase
mitogenic signals
|
|
gptkbp:role
|
apoptosis
cell differentiation
angiogenesis
stem cell maintenance
immune system regulation
neuronal development
tumor suppression
organ development
contact inhibition
cellular quiescence
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:UniProtID
|
P46527
|
|
gptkbp:upregulatedBy
|
cellular stress
|
|
gptkbp:bfsParent
|
gptkb:PI3K-AKT_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|