mammalian target of rapamycin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alsoKnownAs	gptkb:mTOR
gptkbp:associatedWith	gptkb:tuberous_sclerosis gptkb:cancer gptkb:diabetes neurodegenerative diseases
gptkbp:discoveredBy	gptkb:David_M._Sabatini
gptkbp:discoveredIn	1994
gptkbp:EC_number	2.7.11.1
gptkbp:encodedBy	gptkb:MTOR_gene
gptkbp:formsComplexWith	gptkb:mTORC1 gptkb:mTORC2
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	regulation of cell proliferation regulation of cell survival regulation of transcription regulation of cell growth regulation of cell motility regulation of protein synthesis
gptkbp:gene	gptkb:MTOR
https://www.w3.org/2000/01/rdf-schema#label	mammalian target of rapamycin
gptkbp:inhibitedBy	gptkb:everolimus gptkb:rapamycin gptkb:sirolimus gptkb:temsirolimus
gptkbp:member	PI3K-related kinase family
gptkbp:pathway	gptkb:PI3K/AKT/mTOR_pathway
gptkbp:phosphorylates	gptkb:4E-BP1 gptkb:PRAS40 gptkb:S6K1 gptkb:SGK1 gptkb:TSC2 gptkb:ULK1 gptkb:bird gptkb:AKT gptkb:Rictor gptkb:Grb10 gptkb:IRS1 gptkb:TFEB
gptkbp:regulates	metabolism angiogenesis immune response autophagy
gptkbp:subcellularLocation	gptkb:lysosome gptkb:nucleus gptkb:cytoplasm
gptkbp:UniProtID	gptkb:P42345
gptkbp:bfsParent	gptkb:mTOR
gptkbp:bfsLayer	6