|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
gptkb:insulin
gptkb:glucocorticoids
|
|
gptkbp:alias
|
gptkb:SGK
gptkb:SGK1_HUMAN
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes_mellitus
hypertension
|
|
gptkbp:discoveredBy
|
gptkb:Kobayashi_et_al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:SGK1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000118515
6446
|
|
gptkbp:fullName
|
gptkb:serum/glucocorticoid_regulated_kinase_1
|
|
gptkbp:function
|
regulation of cell proliferation
regulation of cell survival
regulation of ion channels
serine/threonine protein kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
10899
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SGK1
|
|
gptkbp:inhibitedBy
|
gptkb:GSK650394
EMD638683
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6q23
|
|
gptkbp:molecularWeight
|
49 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Sgk1
gptkb:rat_Sgk1
|
|
gptkbp:pathway
|
gptkb:PI3K/AKT_signaling_pathway
cellular stress response
|
|
gptkbp:phosphorylates
|
gptkb:ENaC
gptkb:FOXO3a
gptkb:NEDD4L
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:proteinFamily
|
gptkb:AGC_protein_kinase_family
|
|
gptkbp:regulates
|
regulated by insulin
regulated by glucocorticoids
regulated by osmotic stress
regulated by serum
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:tissue_specificity
|
high in colon
high in heart
high in kidney
high in liver
widely expressed
|
|
gptkbp:UniProtID
|
gptkb:O00141
|
|
gptkbp:bfsParent
|
gptkb:mTORC2
|
|
gptkbp:bfsLayer
|
6
|