|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:EIF4EBP1
gptkb:PHAS-1
gptkb:PHAS-I
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:encodedBy
|
gptkb:EIF4EBP1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000187840
1978
|
|
gptkbp:fullName
|
gptkb:Eukaryotic_translation_initiation_factor_4E-binding_protein_1
|
|
gptkbp:function
|
binds eIF4E
regulates translation initiation
|
|
gptkbp:gene
|
gptkb:EIF4EBP1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
4E-BP1
|
|
gptkbp:inhibitedBy
|
cap-dependent translation
|
|
gptkbp:interactsWith
|
gptkb:bird
gptkb:mTORC1
gptkb:eIF4E
|
|
gptkbp:length
|
118 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p12
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~13 kDa
|
|
gptkbp:OMIM
|
601293
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_4E-BP1
gptkb:rat_4E-BP1
|
|
gptkbp:pathway
|
gptkb:mTOR_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
1EJ1
|
|
gptkbp:phosphorylates
|
gptkb:mTOR
leads to release from eIF4E
|
|
gptkbp:phosphorylationSites
|
Ser65
Thr37
Thr46
Thr70
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
gptkb:NM_004095
|
|
gptkbp:regulates
|
regulated by insulin
regulated by growth factors
regulated by stress
|
|
gptkbp:roleInCancer
|
dysregulation associated with tumorigenesis
|
|
gptkbp:roleInMetabolism
|
regulates protein synthesis in response to nutrients
|
|
gptkbp:significance
|
target for cancer therapy
potential biomarker in cancer
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
gptkb:Q13541
|
|
gptkbp:unphosphorylatedForm
|
binds eIF4E
|
|
gptkbp:bfsParent
|
gptkb:mTORC1
|
|
gptkbp:bfsLayer
|
6
|