glycogen synthase kinase-3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:GSK-3
gptkbp:activatedBy	phosphorylation at tyrosine
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:cancer gptkb:diabetes_mellitus bipolar disorder
gptkbp:discoveredBy	1980
gptkbp:encodedBy	gptkb:GSK3A gptkb:GSK3B
gptkbp:enzymeClassification	EC 2.7.11.26
gptkbp:foundIn	gptkb:nucleus gptkb:cytoplasm mitochondria
gptkbp:function	phosphorylation of glycogen synthase
gptkbp:hasIsoform	gptkb:GSK-3α gptkb:GSK-3β
gptkbp:inhibitedBy	gptkb:SB-216763 gptkb:Tideglusib gptkb:CHIR99021 gptkb:valproic_acid lithium phosphorylation at serine
gptkbp:phosphorylates	gptkb:Axin gptkb:cyclin_D1 gptkb:glycogen_synthase gptkb:tau_protein gptkb:CREB gptkb:c-Jun gptkb:NFAT gptkb:APC gptkb:c-Myc gptkb:MCL-1 gptkb:p53 gptkb:beta-catenin gptkb:IRS-1 Snail
gptkbp:regulates	gptkb:Wnt_signaling_pathway apoptosis cell proliferation gene expression glycogen metabolism insulin signaling pathway
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:bfsParent	gptkb:SB-216763
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	glycogen synthase kinase-3