glycogen synthase kinase-3

URI: https://gptkb.org/entity/glycogen_synthase_kinase-3
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation gptkb:GSK-3
gptkbp:activatedBy phosphorylation at tyrosine
gptkbp:associatedWith gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
gptkbp:discoveredBy 1980
gptkbp:encodedBy gptkb:GSK3A
gptkb:GSK3B
gptkbp:enzymeClassification EC 2.7.11.26
gptkbp:foundIn gptkb:nucleus
gptkb:cytoplasm
mitochondria
gptkbp:function phosphorylation of glycogen synthase
gptkbp:hasIsoform gptkb:GSK-3α
gptkb:GSK-3β
https://www.w3.org/2000/01/rdf-schema#label glycogen synthase kinase-3
gptkbp:inhibitedBy gptkb:SB-216763
gptkb:Tideglusib
gptkb:CHIR99021
gptkb:valproic_acid
lithium
phosphorylation at serine
gptkbp:phosphorylates gptkb:Axin
gptkb:cyclin_D1
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:CREB
gptkb:c-Jun
gptkb:NFAT
gptkb:APC
gptkb:c-Myc
gptkb:MCL-1
gptkb:p53
gptkb:beta-catenin
gptkb:IRS-1
Snail
gptkbp:regulates gptkb:Wnt_signaling_pathway
apoptosis
cell proliferation
gene expression
glycogen metabolism
insulin signaling pathway
gptkbp:species gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:bfsParent gptkb:SB-216763
gptkb:GSK-3_inhibitor_VIII
gptkbp:bfsLayer 7