Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
calcium signaling
calcineurin |
| gptkbp:associatedWith |
autoimmune diseases
inflammatory response |
| gptkbp:binds |
gptkb:gene
|
| gptkbp:database |
gptkb:GeneCards
gptkb:NCBI_Gene gptkb:UniProt |
| gptkbp:dephosphorylated_by |
calcineurin
|
| gptkbp:discoveredBy |
Anjana Rao
|
| gptkbp:expressedIn |
gptkb:B_lymphocytes
T lymphocytes other immune cells |
| gptkbp:function |
transcription factor
|
| gptkbp:gene |
gptkb:NFATC2
NFATC4 NFAT5 NFATC1 NFATC3 |
| https://www.w3.org/2000/01/rdf-schema#label |
NFAT
|
| gptkbp:interactsWith |
gptkb:AP-1_transcription_factor
|
| gptkbp:involves |
cancer progression
immune response neuronal development cardiac development skeletal muscle development |
| gptkbp:locale |
cytoplasm (inactive)
nucleus (active) |
| gptkbp:member |
NFATc3
NFATc4 NFAT5 NFATc1 NFATc2 |
| gptkbp:pathway |
gptkb:T_cell_receptor_signaling_pathway
calcium signaling pathway immune system pathway |
| gptkbp:phosphorylated |
inactive state
|
| gptkbp:regulates |
T cell activation
developmental processes cytokine production IL-2 gene expression gene expression in T cells |
| gptkbp:standsFor |
Nuclear Factor of Activated T-cells
|
| gptkbp:structure |
contains Rel homology domain
|
| gptkbp:target |
gptkb:tacrolimus
immunosuppressive drugs cyclosporin A |
| gptkbp:bfsParent |
gptkb:B_cell_receptor_signaling_pathway
|
| gptkbp:bfsLayer |
7
|