|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:GSK3
gptkb:Glycogen_synthase_kinase-3
|
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gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:cofactor
|
Mg2+
|
|
gptkbp:discoveredBy
|
gptkb:Dale_E._Krebs
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:EC_number
|
2.7.11.26
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase_3
|
|
gptkbp:function
|
phosphorylates and inactivates glycogen synthase
|
|
gptkbp:gene
|
gptkb:GSK3A
gptkb:GSK3B
|
|
gptkbp:hasIsoform
|
gptkb:GSK-3α
gptkb:GSK-3β
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK-3
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:Tideglusib
gptkb:CHIR99021
lithium
|
|
gptkbp:involvedIn
|
gptkb:Wnt_signaling_pathway
apoptosis
neurogenesis
glycogen metabolism
insulin signaling pathway
cellular proliferation
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:PDB
|
gptkb:1PYX
gptkb:1Q4L
|
|
gptkbp:phosphorylates
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:CREB
gptkb:β-catenin
|
|
gptkbp:regulates
|
activated by phosphorylation
inhibited by insulin
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:substrate
|
gptkb:ATP
protein substrates
|
|
gptkbp:UniProtID
|
gptkb:P49840
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:AKT_(protein_kinase_B)
gptkb:CHIR99021
gptkb:AKT
gptkb:GSK3
|
|
gptkbp:bfsLayer
|
6
|