|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:GSK3B
gptkb:glycogen_synthase_kinase-3_beta
gptkb:serine/threonine-protein_kinase_GSK3B
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:clinicalTrialDrugTarget
|
gptkb:Tideglusib
gptkb:LY2090314
|
|
gptkbp:discoveredBy
|
gptkb:Dale_E._Koshland_Jr.
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.7.11.26
|
|
gptkbp:family
|
serine/threonine protein kinase
|
|
gptkbp:fullName
|
gptkb:Glycogen_synthase_kinase_3_beta
|
|
gptkbp:function
|
regulation of apoptosis
regulation of cell proliferation
regulation of Wnt signaling pathway
phosphorylation of glycogen synthase
|
|
gptkbp:gene
|
gptkb:GSK3B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GSK-3β
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:Tideglusib
gptkb:CHIR99021
gptkb:lithium_chloride
|
|
gptkbp:locatedOnChromosome
|
chromosome 3q13.33
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:GSK-3α
gptkb:Drosophila_shaggy
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
gptkb:Wnt_signaling_pathway
insulin signaling pathway
|
|
gptkbp:PDB
|
gptkb:1Q4L
|
|
gptkbp:phosphorylates
|
Ser9
Tyr216
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
activated by phosphorylation at Tyr216
inhibited by phosphorylation at Ser9
|
|
gptkbp:substrate
|
gptkb:glycogen_synthase
gptkb:tau_protein
gptkb:beta-catenin
|
|
gptkbp:tissue_specificity
|
ubiquitous
|
|
gptkbp:UniProtID
|
gptkb:P49841
|
|
gptkbp:bfsParent
|
gptkb:CHIR99021
gptkb:GSK3
gptkb:Wnt_signaling_pathway
gptkb:beta-catenin
gptkb:Catenin_beta-1
|
|
gptkbp:bfsLayer
|
6
|