|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:BCL2L3
EAT
MCL1-ES
MCL1-L
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
|
|
gptkbp:discoveredBy
|
Kozopas et al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:MCL1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000143384
|
|
gptkbp:expressedIn
|
cardiac muscle
neurons
hematopoietic cells
|
|
gptkbp:family
|
gptkb:Bcl-2_family
|
|
gptkbp:fullName
|
gptkb:Myeloid_cell_leukemia_1
|
|
gptkbp:function
|
anti-apoptotic protein
|
|
gptkbp:gene
|
gptkb:MCL1
|
|
gptkbp:HGNC_ID
|
6943
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MCL-1
|
|
gptkbp:interactsWith
|
gptkb:BAX
gptkb:NOXA
gptkb:PUMA
gptkb:BAK
BIM
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_1q21
|
|
gptkbp:location
|
mitochondrial membrane
|
|
gptkbp:molecularWeight
|
37 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
cardiomyopathy
|
|
gptkbp:OMIM
|
159552
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:overexpressedIn
|
various cancers
|
|
gptkbp:PDB
|
2MHS
5FDO
6FS0
|
|
gptkbp:phosphorylates
|
protein stability
|
|
gptkbp:RefSeq
|
NM_021960
|
|
gptkbp:regulates
|
apoptosis
|
|
gptkbp:role
|
cell survival
neural development
hematopoiesis
cardiac function
chemoresistance
|
|
gptkbp:target
|
gptkb:BH3_mimetics
S63845
AMG 176
AZD5991
|
|
gptkbp:UniProtID
|
gptkb:Q07820
|
|
gptkbp:bfsParent
|
gptkb:MCL1
|
|
gptkbp:bfsLayer
|
7
|