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gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:CD120a
gptkb:TNFR1
p55
TNFAR
|
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gptkbp:associatedWith
|
Multiple sclerosis
Rheumatoid arthritis
Tumor necrosis factor receptor-associated periodic syndrome
|
|
gptkbp:discoveredBy
|
early 1990s
|
|
gptkbp:encodes
|
TNF receptor 1
|
|
gptkbp:Entrez_Gene_ID
|
7132
ENSG00000067182
|
|
gptkbp:expressedIn
|
many tissues including immune cells
|
|
gptkbp:fullName
|
Tumor necrosis factor receptor superfamily member 1A
|
|
gptkbp:function
|
mediates the majority of the biological activities of TNF-alpha
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
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gptkbp:HGNC_ID
|
gptkb:TNFRSF1A
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFRSF1A gene
|
|
gptkbp:interactsWith
|
gptkb:TNF-alpha
gptkb:FADD
gptkb:TRADD
gptkb:TRAF2
gptkb:RIPK1
|
|
gptkbp:length
|
10 exons
|
|
gptkbp:locatedOnChromosome
|
12
12p13.2
|
|
gptkbp:mutationAssociatedWith
|
can cause TRAPS (TNF receptor-associated periodic syndrome)
|
|
gptkbp:OMIM
|
191190
|
|
gptkbp:orthologIn
|
mouse Tnfrsf1a
rat Tnfrsf1a
|
|
gptkbp:pathway
|
gptkb:TNF_signaling_pathway
Apoptosis
NF-kappa B signaling pathway
|
|
gptkbp:product
|
gptkb:TNFR1
|
|
gptkbp:regulates
|
apoptosis
cell survival
inflammation
|
|
gptkbp:UniProtID
|
P19438
|
|
gptkbp:bfsParent
|
gptkb:TNFR1
|
|
gptkbp:bfsLayer
|
7
|