|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD120a
gptkb:TNFRSF1A
|
|
gptkbp:associatedWith
|
multiple sclerosis
autoimmune diseases
rheumatoid arthritis
familial periodic fever syndromes
|
|
gptkbp:binds
|
gptkb:TNF-alpha
gptkb:TNF-beta
|
|
gptkbp:discoveredBy
|
1990s
|
|
gptkbp:domain
|
death domain
extracellular cysteine-rich domain
|
|
gptkbp:encodedBy
|
gptkb:TNFRSF1A_gene
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Tumor_necrosis_factor_receptor_1
|
|
gptkbp:function
|
involved in inflammation
regulates immune response
mediates apoptosis
activates NF-kappaB pathway
|
|
gptkbp:gene
|
gptkb:TNFRSF1A
|
|
gptkbp:HGNC_ID
|
11916
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNF-R1
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:TRADD
gptkb:TRAF2
gptkb:RIPK1
|
|
gptkbp:launched
|
caspase cascade
|
|
gptkbp:locatedOnChromosome
|
12p13.2
|
|
gptkbp:location
|
gptkb:plasma_membrane
cytoplasm (after cleavage)
|
|
gptkbp:OMIM
|
191190
|
|
gptkbp:PDB
|
gptkb:1EXT
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
P19438
|
|
gptkbp:bfsParent
|
gptkb:TNFR1
|
|
gptkbp:bfsLayer
|
7
|