Statements (47)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
gptkb:virus
stress cytokines free radicals bacterial products |
| gptkbp:alsoKnownAs |
nuclear factor kappa-light-chain-enhancer of activated B cells pathway
|
| gptkbp:database |
KEGG:hsa04064
Reactome:R-HSA-449147 WikiPathways:WP231 |
| gptkbp:discoveredBy |
gptkb:David_Baltimore
Ranjan Sen |
| gptkbp:discoveredIn |
1986
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases chronic inflammation |
| gptkbp:geneTarget |
cytokine genes
immune response genes adhesion molecule genes anti-apoptotic genes |
| https://www.w3.org/2000/01/rdf-schema#label |
NF-κB pathway
|
| gptkbp:inhibitedBy |
gptkb:IκB
gptkb:glucocorticoids anti-inflammatory drugs |
| gptkbp:involvesProtein |
gptkb:IκB
gptkb:NF-κB gptkb:IKK_complex p50 p65 p52 RelB c-Rel RelA |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:mechanismOfAction |
translocation of NF-κB to nucleus
activation of IKK complex degradation of IκB |
| gptkbp:regulates |
apoptosis
cell proliferation cell survival inflammation immune response |
| gptkbp:bfsParent |
gptkb:tumor_necrosis_factor_alpha
gptkb:Toll-like_receptor_4_(TLR4) |
| gptkbp:bfsLayer |
6
|