|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:FAS-associated_death_domain_protein
gptkb:Fas-Associated_Death_Domain_protein
gptkb:MORT1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:domain
|
gptkb:death_effector_domain
death domain
|
|
gptkbp:encodedBy
|
gptkb:FADD_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000168040
|
|
gptkbp:fullName
|
gptkb:Fas-Associated_protein_with_Death_Domain
|
|
gptkbp:function
|
adaptor molecule in apoptotic signaling
mediates death receptor-induced apoptosis
|
|
gptkbp:gene
|
gptkb:FADD
|
|
gptkbp:GOID
|
gptkb:GO:0008625
GO:0006915
|
|
gptkbp:HGNC_ID
|
3573
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FADD
|
|
gptkbp:interactsWith
|
gptkb:Fas_receptor
gptkb:TRADD
gptkb:Caspase-8
TNFRSF10A (TRAIL receptor 1)
TNFRSF10B (TRAIL receptor 2)
|
|
gptkbp:involvedIn
|
immune response
extrinsic apoptotic signaling pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:11q13.3
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
23 kDa
|
|
gptkbp:OMIM
|
602457
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:Fas_signaling_pathway
gptkb:TNF_signaling_pathway
gptkb:TRAIL_signaling_pathway
|
|
gptkbp:PDB
|
gptkb:2GF5
|
|
gptkbp:phosphorylates
|
Ser194
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:RefSeq
|
gptkb:NM_003824
|
|
gptkbp:regulates
|
cell death
caspase activation
NF-kappaB signaling
|
|
gptkbp:requires
|
embryonic development
lymphocyte homeostasis
|
|
gptkbp:UniProtID
|
gptkb:Q13158
|
|
gptkbp:bfsParent
|
gptkb:Fas
gptkb:Fas_receptor
|
|
gptkbp:bfsLayer
|
6
|