TNF receptor superfamily member 1A

URI: https://gptkb.org/entity/TNF_receptor_superfamily_member_1A
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:CD120a
gptkb:TNFR1
gptkb:TNFRSF1A
p55
gptkbp:associatedWith gptkb:TRAPS_(TNF_receptor-associated_periodic_syndrome)
multiple sclerosis
autoimmune diseases
rheumatoid arthritis
gptkbp:domain death domain
gptkbp:encodedBy gptkb:TNFRSF1A_gene
gptkbp:Entrez_Gene_ID 7132
gptkbp:expressedIn gptkb:hepatocytes
endothelial cells
immune cells
gptkbp:function involved in inflammation
mediates apoptosis
activates NF-kappaB pathway
receptor for tumor necrosis factor alpha
gptkbp:hasCytoplasmicDomain yes
gptkbp:hasExtracellularDomain yes
gptkbp:hasPolymorphism C30R
R92Q
gptkbp:HGNC_ID 11916
https://www.w3.org/2000/01/rdf-schema#label TNF receptor superfamily member 1A
gptkbp:interactsWith gptkb:FADD
gptkb:TRADD
gptkb:TRAF2
gptkb:RIPK1
gptkbp:length 455 amino acids
gptkbp:ligand gptkb:TNF-alpha
gptkb:lymphotoxin-alpha
gptkbp:locatedOnChromosome gptkb:chromosome_12
gptkbp:location gptkb:plasma_membrane
gptkbp:molecularWeight 55 kDa
gptkbp:OMIM 191190
gptkbp:orthologInMouse Tnfrsf1a
gptkbp:PDB gptkb:1EXT
gptkbp:postTranslationalModification phosphorylation
glycosylation
ubiquitination
gptkbp:transmembraneDomains yes
gptkbp:type gptkb:MAPK_pathway
apoptosis
cell survival
inflammation
NF-kappaB activation
gptkbp:UniProtID P19438
gptkbp:bfsParent gptkb:TNFR1
gptkbp:bfsLayer 7