TNF receptor superfamily member 1A

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:CD120a gptkb:TNFR1 gptkb:TNFRSF1A p55
gptkbp:associatedWith	gptkb:TRAPS_(TNF_receptor-associated_periodic_syndrome) multiple sclerosis autoimmune diseases rheumatoid arthritis
gptkbp:domain	death domain
gptkbp:encodedBy	gptkb:TNFRSF1A_gene
gptkbp:Entrez_Gene_ID	7132
gptkbp:expressedIn	gptkb:hepatocytes endothelial cells immune cells
gptkbp:function	involved in inflammation mediates apoptosis activates NF-kappaB pathway receptor for tumor necrosis factor alpha
gptkbp:hasCytoplasmicDomain	yes
gptkbp:hasExtracellularDomain	yes
gptkbp:hasPolymorphism	C30R R92Q
gptkbp:HGNC_ID	11916
gptkbp:interactsWith	gptkb:FADD gptkb:TRADD gptkb:TRAF2 gptkb:RIPK1
gptkbp:length	455 amino acids
gptkbp:ligand	gptkb:TNF-alpha gptkb:lymphotoxin-alpha
gptkbp:locatedOnChromosome	gptkb:chromosome_12
gptkbp:location	gptkb:plasma_membrane
gptkbp:molecularWeight	55 kDa
gptkbp:OMIM	191190
gptkbp:orthologInMouse	Tnfrsf1a
gptkbp:PDB	gptkb:1EXT
gptkbp:postTranslationalModification	phosphorylation glycosylation ubiquitination
gptkbp:transmembraneDomains	yes
gptkbp:type	gptkb:MAPK_pathway apoptosis cell survival inflammation NF-kappaB activation
gptkbp:UniProtID	P19438
gptkbp:bfsParent	gptkb:CD120a gptkb:TNFR1
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	TNF receptor superfamily member 1A