|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:TNF-alpha
gptkb:cachectin
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
psoriasis
septic shock
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
apoptosis
cell differentiation
cell proliferation
cell signaling
inflammation
immune response
necrosis
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
extracellular space
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:TNF_gene
|
|
gptkbp:Entrez_Gene_ID
|
7124
ENSG00000232810
|
|
gptkbp:expressedIn
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
gptkb:Tumor_Necrosis_Factor
|
|
gptkbp:function
|
cytokine
induces apoptosis
regulates immune cells
mediates inflammation
|
|
gptkbp:gene
|
gptkb:TNF
|
|
gptkbp:HGNC_ID
|
11892
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNF
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.3
|
|
gptkbp:molecularWeight
|
17 kDa
|
|
gptkbp:OMIM
|
191160
|
|
gptkbp:orthologIn
|
gptkb:mouse_TNF
gptkb:rat_TNF
|
|
gptkbp:pathway
|
gptkb:JNK_signaling_pathway
gptkb:MAPK_signaling_pathway
NF-kappaB signaling
apoptosis pathway
|
|
gptkbp:recipient
|
gptkb:TNFR1
gptkb:TNFR2
|
|
gptkbp:regulates
|
downregulated by glucocorticoids
upregulated by infection
upregulated by inflammation
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:golimumab
gptkb:infliximab
gptkb:certolizumab_pegol
gptkb:adalimumab
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:EGR1
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|