Tumor necrosis factor receptor 1

URI: https://gptkb.org/entity/Tumor_necrosis_factor_receptor_1
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeName gptkb:CD120a
gptkb:TNFR1
p55
p60
gptkbp:associatedWith gptkb:TRAPS_(TNF_receptor-associated_periodic_syndrome)
autoimmune diseases
inflammatory diseases
gptkbp:binds gptkb:tumor_necrosis_factor_alpha
gptkbp:domain death domain
gptkbp:EC_number none
gptkbp:encodedBy gptkb:TNFRSF1A_gene
gptkbp:Entrez_Gene_ID 7132
ENSG00000067182
gptkbp:expressedIn many tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function involved in inflammation
mediates apoptosis
activates NF-kappaB pathway
gptkbp:GO GO:0007165
GO:0006915
GO:0006954
GO:0005031
gptkbp:hasPfam PF00020
gptkbp:hasReactome R-HSA-5669034
gptkbp:hasRefSeqID NM_001065
gptkbp:HGNC_ID 11916
https://www.w3.org/2000/01/rdf-schema#label Tumor necrosis factor receptor 1
gptkbp:interactsWith gptkb:FADD
gptkb:TRADD
gptkb:TRAF2
gptkb:RIPK1
gptkbp:InterPro IPR001368
gptkbp:KEGGID hsa:7132
gptkbp:length 455 amino acids
gptkbp:ligand gptkb:TNF-alpha
gptkb:lymphotoxin-alpha
gptkbp:locatedOnChromosome 12p13.2
gptkbp:location gptkb:cell_membrane
gptkbp:molecularWeight 48 kDa
gptkbp:OMIM 191190
gptkbp:PDB gptkb:1EXT
1FT4
1NCF
gptkbp:target therapeutic antibodies
gptkbp:UniProtID P19438
gptkbp:bfsParent gptkb:TNFR1
gptkbp:bfsLayer 7