|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CD120a
gptkb:TNFR1
gptkb:TNF-R1
p55
TNF-R55
TNFAR
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
multiple sclerosis
rheumatoid arthritis
TRAPS (Tumor necrosis factor receptor-associated periodic syndrome)
|
|
gptkbp:discoveredBy
|
studies of TNF signaling
|
|
gptkbp:encodes
|
Tumor necrosis factor receptor superfamily member 1A
|
|
gptkbp:Entrez_Gene_ID
|
7132
ENSG00000067182
|
|
gptkbp:expressedIn
|
gptkb:hepatocytes
many tissues
neurons
endothelial cells
immune cells
|
|
gptkbp:function
|
involved in inflammation
regulates immune response
mediates TNF-alpha induced apoptosis
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11916
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNFRSF1A
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:TRADD
gptkb:TRAF2
gptkb:RIPK1
TNF (tumor necrosis factor)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12p13.2
|
|
gptkbp:memberOf
|
gptkb:tumor_necrosis_factor_receptor_superfamily
|
|
gptkbp:molecularWeight
|
55 kDa
|
|
gptkbp:mutationAssociatedWith
|
autoinflammatory syndromes
|
|
gptkbp:numberOfExons
|
10
|
|
gptkbp:OMIM
|
191190
|
|
gptkbp:orthologInMouse
|
Tnfrsf1a
|
|
gptkbp:product
|
gptkb:TNFR1
|
|
gptkbp:regulates
|
cell survival
inflammatory response
cell death
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:type
|
gptkb:MAPK_pathway
gptkb:NF-kappaB_pathway
apoptosis pathway
|
|
gptkbp:UniProtID
|
P19438
|
|
gptkbp:bfsParent
|
gptkb:TNFR1
|
|
gptkbp:bfsLayer
|
7
|