|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
RIP
RIP1
Serine/threonine-protein kinase RIP
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
autoimmune diseases
inflammatory diseases
|
|
gptkbp:discoveredBy
|
Yuan et al.
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:domain
|
kinase domain
death domain
intermediate domain
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
RIPK1 gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000137275
|
|
gptkbp:enzymeClassification
|
serine/threonine-protein kinase
|
|
gptkbp:fullName
|
Receptor-interacting serine/threonine-protein kinase 1
|
|
gptkbp:function
|
apoptosis
regulation of cell death
inflammatory signaling
necroptosis
|
|
gptkbp:gene
|
gptkb:RIPK1
|
|
gptkbp:GO
|
GO:0006915
GO:0004672
GO:0006468
|
|
gptkbp:HGNC_ID
|
10019
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RIPK1
|
|
gptkbp:interactsWith
|
gptkb:FADD
gptkb:TNFR1
gptkb:TRADD
gptkb:Caspase-8
gptkb:MLKL
gptkb:RIPK3
|
|
gptkbp:length
|
671 amino acids
|
|
gptkbp:locatedOnChromosome
|
6p25.2
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
76 kDa
|
|
gptkbp:OMIM
|
603453
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
4NEU
5HX6
6C3E
|
|
gptkbp:phosphorylates
|
Ser166
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
cleavage by caspase-8
|
|
gptkbp:RefSeq
|
NP_003795.2
|
|
gptkbp:UniProtID
|
Q13546
|
|
gptkbp:bfsParent
|
gptkb:Death_Domain
gptkb:TNFAIP3
gptkb:Receptor-interacting_protein_kinase_(RIPK)_family
gptkb:TNFR1
|
|
gptkbp:bfsLayer
|
7
|