|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alternativeName
|
gptkb:TNF-alpha
gptkb:cachectin
|
|
gptkbp:associatedWith
|
gptkb:Crohn's_disease
psoriasis
septic shock
rheumatoid arthritis
|
|
gptkbp:category
|
immune system protein
signaling protein
pro-inflammatory cytokine
|
|
gptkbp:discoveredBy
|
gptkb:Lloyd_J._Old
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:encodedBy
|
gptkb:TNF_gene
|
|
gptkbp:Entrez_Gene_ID
|
7124
|
|
gptkbp:fullName
|
gptkb:Tumor_Necrosis_Factor_alpha
|
|
gptkbp:function
|
induces apoptosis
induces fever
regulates immune cells
mediates inflammation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNF-α
|
|
gptkbp:inhibitedBy
|
gptkb:thalidomide
pentoxifylline
|
|
gptkbp:involvedIn
|
apoptosis
cell signaling
immune response
necrosis
acute phase reaction
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.3
|
|
gptkbp:molecularWeight
|
17 kDa (monomer)
|
|
gptkbp:PDB
|
gptkb:2TNF
|
|
gptkbp:producedBy
|
gptkb:natural_killer_cells
gptkb:T_cells
macrophages
|
|
gptkbp:recipient
|
gptkb:TNFR1
gptkb:TNFR2
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
homotrimer
|
|
gptkbp:target
|
gptkb:etanercept
gptkb:infliximab
gptkb:adalimumab
|
|
gptkbp:UniProtID
|
gptkb:P01375
|
|
gptkbp:bfsParent
|
gptkb:tumor_necrosis_factor_alpha
|
|
gptkbp:bfsLayer
|
6
|