|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
Tumor necrosis factor receptor superfamily
|
|
gptkbp:characteristic
|
contains cysteine-rich domains
|
|
gptkbp:contains
|
gptkb:CD95
gptkb:DR4
gptkb:DR5
gptkb:DR3
gptkb:CD30
gptkb:CD120a
gptkb:CD120b
gptkb:CD137
gptkb:CD27
gptkb:CD40
gptkb:OX40
gptkb:RANK
gptkb:TNFR1
gptkb:TNFR2
gptkb:4-1BB
gptkb:GITR
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:foundIn
|
mammals
vertebrates
|
|
gptkbp:function
|
binds tumor necrosis factors
mediates cell signaling
|
|
gptkbp:GO_term
|
GO:0005031
|
|
gptkbp:hasPfam
|
PF00020
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TNF receptor superfamily
|
|
gptkbp:InterPro
|
IPR001368
|
|
gptkbp:involvedIn
|
apoptosis
inflammation
immune regulation
|
|
gptkbp:ligand
|
gptkb:TNF-alpha
gptkb:Fas_ligand
gptkb:TRAIL
gptkb:CD40_ligand
gptkb:RANKL
|
|
gptkbp:orthologIn
|
Drosophila Wengen
|
|
gptkbp:regulates
|
gptkb:MAPK_pathway
gptkb:NF-kappaB_pathway
apoptotic signaling pathway
immune cell activation
|
|
gptkbp:relatedTo
|
gptkb:cancer
autoimmune diseases
inflammatory diseases
cell death
|
|
gptkbp:significance
|
target for cancer therapy
target for immunotherapy
target for anti-inflammatory drugs
|
|
gptkbp:transmembraneDomains
|
true
|
|
gptkbp:bfsParent
|
gptkb:Fas
|
|
gptkbp:bfsLayer
|
6
|