sterol regulatory element-binding protein 1c

URI: https://gptkb.org/entity/sterol_regulatory_element-binding_protein_1c
GPTKB entity
Statements (34)
Predicate Object
gptkbp:instanceOf gptkb:transcription_factor
gptkb:protein
gptkbp:activatedBy gptkb:insulin
gptkbp:alternativeName gptkb:SREBP-1c
bHLHd1
SREBF1c
gptkbp:binds sterol regulatory element (SRE)
gptkbp:cleavage gptkb:site-1_protease_(S1P)
gptkb:site-2_protease_(S2P)
gptkbp:domain basic helix-loop-helix leucine zipper domain
gptkbp:encodedBy gptkb:SREBF1_gene
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:locatedIn gptkb:nucleus
gptkbp:locatedOnChromosome 17p11.2
gptkbp:memberOf gptkb:SREBP_family
gptkbp:OMIM 184756
gptkbp:precursorLocatedIn endoplasmic reticulum membrane
gptkbp:regulates gptkb:SREBF1_gene
fatty acid synthesis
downregulated by polyunsaturated fatty acids
upregulated by insulin
lipid biosynthesis
triglyceride synthesis
downregulated by cholesterol
ACACA gene
ACLY gene
ELOVL6 gene
FASN gene
GPAM gene
SCD1 gene
gptkbp:UniProtID P36956
gptkbp:bfsParent gptkb:SREBP-1c
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label sterol regulatory element-binding protein 1c