Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
proteolytic cleavage
|
| gptkbp:discoveredBy |
Brown and Goldstein
|
| gptkbp:domain |
basic helix-loop-helix leucine zipper domain
|
| gptkbp:encodedBy |
gptkb:SREBF1_gene
SREBF2 gene |
| gptkbp:expressedIn |
mammals
|
| gptkbp:fullName |
Sterol regulatory element-binding protein family
|
| gptkbp:function |
regulation of lipid homeostasis
regulation of cholesterol biosynthesis regulation of fatty acid metabolism |
| https://www.w3.org/2000/01/rdf-schema#label |
SREBP family
|
| gptkbp:locale |
gptkb:endoplasmic_reticulum
gptkb:nucleus |
| gptkbp:member |
gptkb:SREBP-2
SREBP-1 |
| gptkbp:regulates |
gptkb:HMG-CoA_reductase
gptkb:fatty_acid_synthase gptkb:LDL_receptor |
| gptkbp:relatedTo |
atherosclerosis
lipid metabolism disorders |
| gptkbp:bfsParent |
gptkb:SREBP-1c
|
| gptkbp:bfsLayer |
7
|