glucose-6-phosphate dehydrogenase (G6PD)

URI: https://gptkb.org/entity/glucose-6-phosphate_dehydrogenase_(G6PD)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:G6PD
gptkb:G6PDH
glucose-6-phosphate:NADP+ oxidoreductase
gptkbp:associatedWith gptkb:chronic_non-spherocytic_hemolytic_anemia
gptkb:neonatal_jaundice
gptkbp:biologicalProcess oxidoreductase activity
gptkbp:CASNumber 9001-40-5
gptkbp:catalyzes oxidation of glucose-6-phosphate to 6-phosphoglucono-δ-lactone
gptkbp:cofactor NADP+
gptkbp:deficiencyCauses gptkb:G6PD_deficiency
gptkbp:discoveredBy gptkb:Ernest_Beutler
gptkbp:EC_number 1.1.1.49
gptkbp:expressedIn all human tissues
gptkbp:firstDescribed 1950s
gptkbp:foundIn gptkb:cytoplasm
gptkbp:gene gptkb:G6PD
gptkbp:gene_location_(human) gptkb:Xq28
gptkbp:highest_expression gptkb:adrenal_gland
liver
red blood cells
https://www.w3.org/2000/01/rdf-schema#label glucose-6-phosphate dehydrogenase (G6PD)
gptkbp:importantFor protects red blood cells from oxidative damage
gptkbp:inhibitedBy gptkb:dehydroepiandrosterone_(DHEA)
6-aminonicotinamide
gptkbp:location_(human) gptkb:X_chromosome
gptkbp:molecularWeight 59 kDa
gptkbp:mutationAssociatedWith hemolysis
enzyme deficiency
increased susceptibility to oxidative stress
gptkbp:number_of_amino_acids_(human) 515
gptkbp:OMIM 305900
gptkbp:ortholog_in_E._coli zwf
gptkbp:orthologInMouse gptkb:G6pdx
gptkbp:orthologInYeast ZWF1
gptkbp:pathway gptkb:pentose_phosphate_pathway
gptkbp:PDB 2BH9
gptkbp:product gptkb:6-phosphoglucono-δ-lactone
NADPH
gptkbp:regulates allosteric regulation
hormonal regulation
feedback inhibition by NADPH
gptkbp:significance gptkb:anemia
gptkb:favism
gptkbp:structure homodimer or homotetramer
gptkbp:substrate gptkb:glucose-6-phosphate
NADP+
gptkbp:UniProtID P11413
gptkbp:bfsParent gptkb:SREBP-1c
gptkbp:bfsLayer 7