Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
NADP(+)-dependent malic enzyme
|
| gptkbp:associatedWith |
gptkb:metabolic_syndrome
cancer metabolism |
| gptkbp:catalyzes |
oxidative decarboxylation of malate to pyruvate
|
| gptkbp:cofactor |
NADP+
|
| gptkbp:EC_number |
1.1.1.40
|
| gptkbp:encodedBy |
ME1 gene
|
| gptkbp:expressedIn |
liver
adipose tissue pancreas |
| gptkbp:fullName |
malic enzyme 1, NADP(+)-dependent, cytosolic
|
| gptkbp:function |
generates NADPH
involved in lipid biosynthesis |
| gptkbp:gene |
ME1
|
| https://www.w3.org/2000/01/rdf-schema#label |
malic enzyme (ME1)
|
| gptkbp:locatedOnChromosome |
6q14.2
|
| gptkbp:location |
cytosol
|
| gptkbp:OMIM |
154250
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Me1
|
| gptkbp:PDB |
1GQ2
|
| gptkbp:product |
gptkb:pyruvate
CO2 NADPH |
| gptkbp:regulates |
upregulated by insulin
downregulated by starvation |
| gptkbp:structure |
homotetramer
|
| gptkbp:substrate |
malate
|
| gptkbp:UniProtID |
P48163
|
| gptkbp:bfsParent |
gptkb:SREBP-1c
|
| gptkbp:bfsLayer |
7
|