fatty acid synthase (FASN)

URI: https://gptkb.org/entity/fatty_acid_synthase_(FASN)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName gptkb:FASN
gptkb:FAS
gptkbp:associatedWith gptkb:cancer
gptkb:type_2_diabetes
gptkb:non-alcoholic_fatty_liver_disease
obesity
gptkbp:catalyzes palmitate synthesis from acetyl-CoA and malonyl-CoA
gptkbp:cofactor NADPH
gptkbp:EC_number 2.3.1.85
gptkbp:Entrez_Gene_ID 2194
ENSG00000169710
gptkbp:expressedIn liver
adipose tissue
mammary gland
gptkbp:function catalyzes the synthesis of long-chain fatty acids
gptkbp:gene gptkb:FASN
gptkbp:geneType protein-coding
https://www.w3.org/2000/01/rdf-schema#label fatty acid synthase (FASN)
gptkbp:inhibitedBy gptkb:C75
gptkb:cerulenin
gptkb:orlistat
gptkbp:interactsWith gptkb:ACACA
gptkb:SREBF1
PPARĪ³
gptkbp:locatedOnChromosome 17q25.3
gptkbp:location gptkb:cytoplasm
gptkbp:molecularWeight ~273 kDa
gptkbp:OMIM 600212
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Fasn
gptkbp:overexpressedIn gptkb:cancer
prostate cancer
gptkbp:pathway lipogenesis
gptkbp:PDB 2VZ8
gptkbp:product gptkb:palmitate
CO2
NADP+
gptkbp:RefSeq NM_004104
gptkbp:regulates upregulated by insulin
downregulated by fasting
downregulated by leptin
upregulated by SREBP-1c
gptkbp:substrate gptkb:malonyl-CoA
acetyl-CoA
gptkbp:subunit homodimer
gptkbp:UniProtID gptkb:P49327
gptkbp:bfsParent gptkb:SREBP-1c
gptkbp:bfsLayer 7