stearoyl-CoA desaturase-1 (SCD1)

URI: https://gptkb.org/entity/stearoyl-CoA_desaturase-1_(SCD1)
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:alternativeName delta-9 desaturase
gptkbp:associatedWith gptkb:non-alcoholic_fatty_liver_disease
obesity
insulin resistance
gptkbp:catalyzes desaturation of stearoyl-CoA to oleoyl-CoA
gptkbp:cofactor gptkb:NADH
oxygen
cytochrome b5
gptkbp:EC_number 1.14.19.1
gptkbp:encodedBy SCD gene
gptkbp:Entrez_Gene_ID 6319
gptkbp:expressedIn gptkb:adipose_tissue
gptkb:skin
heart
liver
gptkbp:foundIn gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:function biosynthesis of monounsaturated fatty acids
gptkbp:gene SCD
gptkbp:inhibitedBy improved insulin sensitivity
increased fatty acid oxidation
protection against diet-induced obesity
reduced adiposity
reduced triglyceride synthesis
gptkbp:involves lipid metabolism
energy homeostasis
gptkbp:locatedIn gptkb:endoplasmic_reticulum
gptkbp:locatedOnChromosome 10q24.31 (human)
gptkbp:MIM_number 604031
gptkbp:mutationAssociatedWith gptkb:metabolic_syndrome
skin disorders
gptkbp:orthologInMouse gptkb:Scd1
gptkbp:pathway fatty acid biosynthesis
lipogenesis
unsaturated fatty acid biosynthesis
gptkbp:PDB 4YMK
gptkbp:product oleoyl-CoA
gptkbp:regulates regulated by insulin
regulated by SREBP-1c
regulated by leptin
regulated by PPARs
gptkbp:substrate stearoyl-CoA
gptkbp:target SCD1 inhibitors
gptkbp:UniProtID gptkb:O00767
gptkbp:bfsParent gptkb:SREBP-1c
gptkbp:bfsLayer 8
https://www.w3.org/2000/01/rdf-schema#label stearoyl-CoA desaturase-1 (SCD1)