stearoyl-CoA desaturase-1 (SCD1)
GPTKB entity
Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
delta-9 desaturase
|
| gptkbp:associatedWith |
gptkb:non-alcoholic_fatty_liver_disease
obesity insulin resistance |
| gptkbp:catalyzes |
desaturation of stearoyl-CoA to oleoyl-CoA
|
| gptkbp:cofactor |
gptkb:NADH
oxygen cytochrome b5 |
| gptkbp:EC_number |
1.14.19.1
|
| gptkbp:encodedBy |
SCD gene
|
| gptkbp:Entrez_Gene_ID |
6319
|
| gptkbp:expressedIn |
gptkb:skin
heart liver adipose tissue |
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:function |
biosynthesis of monounsaturated fatty acids
|
| gptkbp:gene |
SCD
|
| https://www.w3.org/2000/01/rdf-schema#label |
stearoyl-CoA desaturase-1 (SCD1)
|
| gptkbp:inhibitedBy |
improved insulin sensitivity
increased fatty acid oxidation protection against diet-induced obesity reduced adiposity reduced triglyceride synthesis |
| gptkbp:involves |
lipid metabolism
energy homeostasis |
| gptkbp:locatedIn |
gptkb:endoplasmic_reticulum
|
| gptkbp:locatedOnChromosome |
10q24.31 (human)
|
| gptkbp:MIM_number |
604031
|
| gptkbp:mutationAssociatedWith |
gptkb:metabolic_syndrome
skin disorders |
| gptkbp:orthologInMouse |
gptkb:Scd1
|
| gptkbp:pathway |
fatty acid biosynthesis
lipogenesis unsaturated fatty acid biosynthesis |
| gptkbp:PDB |
4YMK
|
| gptkbp:product |
oleoyl-CoA
|
| gptkbp:regulates |
regulated by insulin
regulated by SREBP-1c regulated by leptin regulated by PPARs |
| gptkbp:substrate |
stearoyl-CoA
|
| gptkbp:target |
SCD1 inhibitors
|
| gptkbp:UniProtID |
gptkb:O00767
|
| gptkbp:bfsParent |
gptkb:SREBP-1c
|
| gptkbp:bfsLayer |
7
|