Statements (27)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
S2P
MBTPS2 protein site-2 metalloprotease |
| gptkbp:catalyzes |
cleavage of membrane-bound transcription factors
|
| gptkbp:cleavage |
ATF6 (activating transcription factor 6)
SREBP (sterol regulatory element-binding proteins) |
| gptkbp:cofactor |
zinc
|
| gptkbp:EC_number |
3.4.24.85
|
| gptkbp:foundIn |
gptkb:Bacteria
animals plants |
| gptkbp:function |
intramembrane proteolysis
|
| gptkbp:gene |
MBTPS2
|
| gptkbp:gene_location_(human) |
chromosome Xp22.12
|
| https://www.w3.org/2000/01/rdf-schema#label |
site-2 protease (S2P)
|
| gptkbp:involves |
cholesterol homeostasis
endoplasmic reticulum stress response regulated intramembrane proteolysis (RIP) |
| gptkbp:membrane_location |
gptkb:endoplasmic_reticulum
gptkb:Golgi_apparatus |
| gptkbp:mutationAssociatedWith |
keratosis follicularis spinulosa decalvans (KFSD)
Ichthyosis follicularis, atrichia, and photophobia (IFAP) syndrome |
| gptkbp:proteinFamily |
M50 peptidase family
|
| gptkbp:UniProtID |
Q9Y6A5 (human)
|
| gptkbp:bfsParent |
gptkb:SREBP-1c
|
| gptkbp:bfsLayer |
7
|