Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
proteolytic cleavage
|
| gptkbp:alternativeName |
bHLHd2
|
| gptkbp:discoveredBy |
Brown and Goldstein
|
| gptkbp:domain |
basic helix-loop-helix leucine zipper (bHLH-LZ)
|
| gptkbp:encodedBy |
SREBF2 gene
|
| gptkbp:family |
gptkb:SREBP_family
|
| gptkbp:fullName |
Sterol regulatory element-binding protein 2
|
| gptkbp:function |
transcription factor
regulation of cholesterol homeostasis |
| https://www.w3.org/2000/01/rdf-schema#label |
SREBP-2
|
| gptkbp:locale |
endoplasmic reticulum membrane
nucleus (after activation) |
| gptkbp:locatedOnChromosome |
chromosome 22q13
|
| gptkbp:OMIM |
184756
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:regulates |
gptkb:HMG-CoA_reductase
gptkb:LDL_receptor |
| gptkbp:relatedTo |
lipid metabolism
cholesterol biosynthesis |
| gptkbp:UniProtID |
Q12772
|
| gptkbp:bfsParent |
gptkb:SREBP-1c
|
| gptkbp:bfsLayer |
7
|