|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
ATP-citrate synthase
citrate cleavage enzyme
|
|
gptkbp:associatedWith
|
gptkb:metabolic_syndrome
obesity
cancer metabolism
hyperlipidemia
|
|
gptkbp:catalyzes
|
conversion of citrate and CoA to acetyl-CoA and oxaloacetate
|
|
gptkbp:cofactor
|
gptkb:ATP
|
|
gptkbp:EC_number
|
2.3.3.8
|
|
gptkbp:encodedBy
|
ACLY gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000084073
GC17M037774
|
|
gptkbp:expressedIn
|
gptkb:adipose_tissue
liver
many tissues
|
|
gptkbp:foundIn
|
cytosol
|
|
gptkbp:function
|
links carbohydrate metabolism to lipid synthesis
provides acetyl-CoA for fatty acid synthesis
|
|
gptkbp:gene
|
ACLY
|
|
gptkbp:HGNC_ID
|
166
|
|
gptkbp:inhibitedBy
|
bempedoic acid
hydroxycitrate
|
|
gptkbp:involves
|
cholesterol biosynthesis
lipogenesis
|
|
gptkbp:KEGGID
|
hsa:173
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q12
|
|
gptkbp:molecularWeight
|
~120 kDa (per subunit)
|
|
gptkbp:OMIM
|
600290
|
|
gptkbp:orthologInMouse
|
Acly
|
|
gptkbp:orthologInYeast
|
CIT2
|
|
gptkbp:PDB
|
6O0H
|
|
gptkbp:phosphorylates
|
gptkb:AKT
Ser455
|
|
gptkbp:presentIn
|
animals
humans
plants
|
|
gptkbp:Reactome
|
R-HSA-3728606
|
|
gptkbp:RefSeq
|
NM_001096
|
|
gptkbp:regulates
|
upregulated by insulin
regulated by SREBP-1c
downregulated by fasting
|
|
gptkbp:significance
|
target for lipid-lowering drugs
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
|
|
gptkbp:target
|
bempedoic acid
|
|
gptkbp:UniProtID
|
P53396
|
|
gptkbp:bfsParent
|
gptkb:SREBP-1c
|
|
gptkbp:bfsLayer
|
8
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ATP citrate lyase (ACLY)
|