Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
ATP-citrate synthase
citrate cleavage enzyme |
| gptkbp:associatedWith |
gptkb:metabolic_syndrome
obesity cancer metabolism hyperlipidemia |
| gptkbp:catalyzes |
conversion of citrate and CoA to acetyl-CoA and oxaloacetate
|
| gptkbp:cofactor |
gptkb:ATP
|
| gptkbp:EC_number |
2.3.3.8
|
| gptkbp:encodedBy |
ACLY gene
|
| gptkbp:Entrez_Gene_ID |
ENSG00000084073
GC17M037774 |
| gptkbp:expressedIn |
liver
many tissues adipose tissue |
| gptkbp:foundIn |
cytosol
|
| gptkbp:function |
links carbohydrate metabolism to lipid synthesis
provides acetyl-CoA for fatty acid synthesis |
| gptkbp:gene |
ACLY
|
| gptkbp:HGNC_ID |
166
|
| https://www.w3.org/2000/01/rdf-schema#label |
ATP citrate lyase (ACLY)
|
| gptkbp:inhibitedBy |
bempedoic acid
hydroxycitrate |
| gptkbp:involves |
cholesterol biosynthesis
lipogenesis |
| gptkbp:KEGGID |
hsa:173
|
| gptkbp:locatedOnChromosome |
gptkb:17q12
|
| gptkbp:molecularWeight |
~120 kDa (per subunit)
|
| gptkbp:OMIM |
600290
|
| gptkbp:orthologInMouse |
Acly
|
| gptkbp:orthologInYeast |
CIT2
|
| gptkbp:PDB |
6O0H
|
| gptkbp:phosphorylates |
gptkb:AKT
Ser455 |
| gptkbp:presentIn |
animals
humans plants |
| gptkbp:Reactome |
R-HSA-3728606
|
| gptkbp:RefSeq |
NM_001096
|
| gptkbp:regulates |
upregulated by insulin
regulated by SREBP-1c downregulated by fasting |
| gptkbp:significance |
target for lipid-lowering drugs
|
| gptkbp:structure |
homotetramer
|
| gptkbp:subcellularLocation |
gptkb:cytoplasm
|
| gptkbp:target |
bempedoic acid
|
| gptkbp:UniProtID |
P53396
|
| gptkbp:bfsParent |
gptkb:SREBP-1c
|
| gptkbp:bfsLayer |
7
|