Statements (38)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:insulin
gptkb:liver_X_receptor_(LXR) |
| gptkbp:alternativeSplicing |
SREBP1a
SREBP1b |
| gptkbp:cleavage |
gptkb:site-1_protease_(S1P)
gptkb:site-2_protease_(S2P) |
| gptkbp:encodedBy |
gptkb:SREBF1_gene
|
| gptkbp:fullName |
Sterol regulatory element-binding protein 1c
|
| gptkbp:function |
transcription factor
|
| gptkbp:gene |
gptkb:SREBF1
|
| https://www.w3.org/2000/01/rdf-schema#label |
SREBP1c
|
| gptkbp:involvedIn |
gptkb:type_2_diabetes
gptkb:non-alcoholic_fatty_liver_disease gptkb:metabolic_syndrome obesity cholesterol homeostasis |
| gptkbp:locale |
gptkb:nucleus
endoplasmic reticulum (precursor form) |
| gptkbp:locatedOnChromosome |
17p11.2
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:regulates |
gptkb:FASN
gptkb:PKLR gptkb:ACACA gptkb:G6PD gptkb:SCD1 ME1 fatty acid synthesis lipogenesis triglyceride synthesis THRSP ELOVL6 ACLY GPAM SREBF1 (autoregulation) |
| gptkbp:UniProtID |
gptkb:P36956-2
|
| gptkbp:bfsParent |
gptkb:SREBP-1c
|
| gptkbp:bfsLayer |
7
|