Statements (34)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
transcription factor
nuclear receptor |
| gptkbp:activatesTranscriptionOf |
gptkb:ABCA1
gptkb:ABCG1 gptkb:SREBP-1c |
| gptkbp:alternativeName |
gptkb:LXRα
gptkb:LXRβ gptkb:NR1H2 gptkb:NR1H3 |
| gptkbp:discoveredIn |
1995
|
| gptkbp:encodedBy |
gptkb:NR1H2
gptkb:NR1H3 |
| gptkbp:formsHeterodimerWith |
gptkb:retinoid_X_receptor_(RXR)
|
| gptkbp:foundIn |
liver
adipose tissue macrophages intestine |
| gptkbp:hasIsoform |
gptkb:LXRα
gptkb:LXRβ |
| https://www.w3.org/2000/01/rdf-schema#label |
liver X receptor (LXR)
|
| gptkbp:involvedIn |
atherosclerosis
glucose metabolism fatty acid synthesis |
| gptkbp:ligand |
oxysterols
|
| gptkbp:regulates |
lipid metabolism
inflammation cholesterol metabolism genes involved in reverse cholesterol transport |
| gptkbp:subclassOf |
nuclear receptor
|
| gptkbp:target |
antagonists
agonists |
| gptkbp:bfsParent |
gptkb:SREBP-1c
gptkb:retinoid_X_receptor_(RXR) |
| gptkbp:bfsLayer |
7
|