acetyl-CoA carboxylase (ACC)

URI: https://gptkb.org/entity/acetyl-CoA_carboxylase_(ACC)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activatedBy gptkb:insulin
citrate
gptkbp:alternativeName gptkb:ACC
gptkb:acetyl-CoA_carboxylase_alpha
acetyl-CoA carboxylase beta
gptkbp:catalyzes carboxylation of acetyl-CoA to malonyl-CoA
gptkbp:cofactor gptkb:biotin
gptkbp:EC_number 6.4.1.2
gptkbp:foundIn gptkb:Bacteria
animals
plants
gptkbp:gene gptkb:ACACA
gptkb:ACACB
https://www.w3.org/2000/01/rdf-schema#label acetyl-CoA carboxylase (ACC)
gptkbp:inhibitedBy gptkb:glucagon
gptkb:AMP-activated_protein_kinase_(AMPK)
epinephrine
fatty acyl-CoA
gptkbp:involves fatty acid biosynthesis
gptkbp:locale cytosol
mitochondria (isoform ACC2)
gptkbp:molecularWeight ~265 kDa (human ACC1)
gptkbp:OMIM_ID_(ACACA) 200350
gptkbp:OMIM_ID_(ACACB) 601557
gptkbp:PDB 1DV2
2F9Y
gptkbp:product gptkb:malonyl-CoA
gptkbp:regulates citrate
phosphorylation
palmitoyl-CoA
gptkbp:role gptkb:cancer
gptkb:type_2_diabetes
obesity
gptkbp:structure multifunctional enzyme
gptkbp:substrate gptkb:ATP
bicarbonate
acetyl-CoA
gptkbp:subunit biotin carboxyl carrier protein
biotin carboxylase
carboxyltransferase
gptkbp:target fibrate drugs
TOFA
soraphen A
CP-640186
ND-630
gptkbp:UniProt_ID_(human_ACC1) gptkb:Q13085
gptkbp:UniProt_ID_(human_ACC2) O00763
gptkbp:bfsParent gptkb:SREBP-1c
gptkbp:bfsLayer 7