RB1 (Retinoblastoma protein)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:RB_protein gptkb:pRb
gptkbp:associatedWith	gptkb:cancer gptkb:retinoblastoma bladder cancer Small Cell Lung Cancer osteosarcoma
gptkbp:discoveredBy	gptkb:Weinberg_laboratory
gptkbp:encodedBy	gptkb:RB1_gene
gptkbp:Entrez_Gene_ID	gptkb:RB1 ENSG00000139687
gptkbp:expressedIn	many tissues
gptkbp:firstDescribed	1986
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	tumor suppressor regulation of cell cycle
gptkbp:gene	gptkb:RB1
gptkbp:geneType	tumor suppressor
gptkbp:HGNC_ID	9884
https://www.w3.org/2000/01/rdf-schema#label	RB1 (Retinoblastoma protein)
gptkbp:inhibitedBy	gptkb:E2F_transcription_factors
gptkbp:interactsWith	gptkb:Mdm2 gptkb:Cyclin_D gptkb:Cyclin_E gptkb:BRCA1 gptkb:E2F1 gptkb:HDAC1
gptkbp:length	~180 kb
gptkbp:locatedOnChromosome	gptkb:chromosome_13 13q14.2
gptkbp:molecularWeight	~110 kDa
gptkbp:mutationAssociatedWith	gptkb:small_cell_lung_carcinoma gptkb:retinoblastoma osteosarcoma
gptkbp:numberOfExons	27
gptkbp:OMIM	614041
gptkbp:orthologIn	gptkb:mouse gptkb:zebrafish Drosophila melanogaster (Rbf)
gptkbp:PDB	gptkb:1GUX
gptkbp:phosphorylates	gptkb:CDK2 gptkb:CDK4 gptkb:CDK6
gptkbp:RefSeq	NM_000321
gptkbp:regulates	apoptosis cell differentiation G1/S cell cycle transition chromatin remodeling
gptkbp:UniProtID	P06400
gptkbp:bfsParent	gptkb:Cdk4
gptkbp:bfsLayer	8