|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Cell_division_protein_kinase_4
|
|
gptkbp:component
|
gptkb:cyclin-dependent_protein_kinase_holoenzyme_complex
|
|
gptkbp:discoveredBy
|
gptkb:David_Beach
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:EC_number
|
2.7.11.22
|
|
gptkbp:enzymeClassification
|
serine/threonine kinase
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_4
|
|
gptkbp:function
|
regulation of cell cycle
cyclin-dependent protein serine/threonine kinase activity
|
|
gptkbp:gene
|
gptkb:CDK4
|
|
gptkbp:GOProcess
|
G1/S transition of mitotic cell cycle
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cdk4
|
|
gptkbp:inhibitedBy
|
gptkb:p15INK4b
gptkb:p16INK4a
gptkb:p18INK4c
gptkb:p19INK4d
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_D2
gptkb:Cyclin_D3
gptkb:Cyclin_D1
|
|
gptkbp:locatedOnChromosome
|
12q14
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
34 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_melanoma
pancreatic cancer
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk4
|
|
gptkbp:orthologInZebrafish
|
cdk4
|
|
gptkbp:PDB
|
gptkb:2W96
|
|
gptkbp:phosphorylates
|
gptkb:RB1_(Retinoblastoma_protein)
T172
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
cell proliferation
cell cycle progression
G1 phase progression
entry into S phase
|
|
gptkbp:role
|
gptkb:cancer
gptkb:glioblastoma
gptkb:rhabdomyosarcoma
melanoma
|
|
gptkbp:targetOfDrug
|
gptkb:Abemaciclib
gptkb:Palbociclib
gptkb:Ribociclib
|
|
gptkbp:UniProtID
|
P11802
|
|
gptkbp:bfsParent
|
gptkb:CDK4
|
|
gptkbp:bfsLayer
|
7
|