PI3K-AKT signaling pathway

URI: https://gptkb.org/entity/PI3K-AKT_signaling_pathway
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf signaling molecule
gptkbp:activatedBy gptkb:insulin
gptkb:receptor_tyrosine_kinases
cytokines
growth factors
gptkbp:alsoKnownAs gptkb:PI3K/AKT_pathway
gptkbp:downstreamOf PI3K activation
mTOR signaling
gptkbp:dysregulationAssociatedWith gptkb:cancer
gptkb:diabetes
neurodegenerative diseases
cardiovascular diseases
gptkbp:foundIn eukaryotic cells
https://www.w3.org/2000/01/rdf-schema#label PI3K-AKT signaling pathway
gptkbp:inhibitedBy AKT inhibitors
PI3K inhibitors
mTOR inhibitors
gptkbp:involves gptkb:AKT_(protein_kinase_B)
gptkb:PI3K_(phosphoinositide_3-kinase)
gptkb:PTEN_(phosphatase_and_tensin_homolog)
gptkb:mTOR_(mechanistic_target_of_rapamycin)
PDK1 (3-phosphoinositide-dependent protein kinase-1)
gptkbp:modulatedBy gptkb:CREB
gptkb:BAD_(Bcl-2-associated_death_promoter)
gptkb:p21Cip1
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:PTEN
gptkb:TSC1/TSC2_complex
gptkb:mTORC1
gptkb:mTORC2
gptkb:NF-κB
gptkb:eNOS
gptkb:p27Kip1
GSK3 (glycogen synthase kinase 3)
gptkbp:regulates apoptosis
cell proliferation
cell survival
metabolism
angiogenesis
cell growth
cell migration
gptkbp:studiedIn cancer research
immunology
neuroscience
metabolic disease research
gptkbp:bfsParent gptkb:RET_proto-oncogene
gptkbp:bfsLayer 5