PI3K-AKT signaling pathway

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:signaling_molecule
gptkbp:activatedBy	gptkb:insulin gptkb:receptor_tyrosine_kinases cytokines growth factors
gptkbp:alsoKnownAs	gptkb:PI3K/AKT_pathway
gptkbp:downstreamOf	PI3K activation mTOR signaling
gptkbp:dysregulationAssociatedWith	gptkb:cancer gptkb:diabetes neurodegenerative diseases cardiovascular diseases
gptkbp:foundIn	eukaryotic cells
gptkbp:inhibitedBy	AKT inhibitors PI3K inhibitors mTOR inhibitors
gptkbp:involves	gptkb:AKT_(protein_kinase_B) gptkb:PI3K_(phosphoinositide_3-kinase) gptkb:PTEN_(phosphatase_and_tensin_homolog) gptkb:mTOR_(mechanistic_target_of_rapamycin) PDK1 (3-phosphoinositide-dependent protein kinase-1)
gptkbp:modulatedBy	gptkb:CREB gptkb:BAD_(Bcl-2-associated_death_promoter) gptkb:p21Cip1 gptkb:FOXO_transcription_factors gptkb:MDM2 gptkb:PTEN gptkb:TSC1/TSC2_complex gptkb:mTORC1 gptkb:mTORC2 gptkb:NF-κB gptkb:eNOS gptkb:p27Kip1 GSK3 (glycogen synthase kinase 3)
gptkbp:regulates	apoptosis cell proliferation cell survival metabolism angiogenesis cell growth cell migration
gptkbp:studiedIn	cancer research immunology neuroscience metabolic disease research
gptkbp:bfsParent	gptkb:Ki-ras gptkb:Kras
gptkbp:bfsLayer	6
https://www.w3.org/2000/01/rdf-schema#label	PI3K-AKT signaling pathway