mTOR (mechanistic target of rapamycin)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:activatedBy	gptkb:insulin growth factors amino acids nutrients
gptkbp:alternativeName	gptkb:mammalian_target_of_rapamycin gptkb:mechanistic_target_of_rapamycin gptkb:FK506-binding_protein_12-rapamycin-associated_protein_1 gptkb:FRAP1
gptkbp:associatedWith	gptkb:cancer gptkb:diabetes aging neurodegenerative diseases
gptkbp:biologicalProcess	serine/threonine kinase activity
gptkbp:component	gptkb:mTORC1 gptkb:mTORC2
gptkbp:discoveredBy	gptkb:David_M._Sabatini
gptkbp:discoveredIn	1994
gptkbp:EC_number	2.7.11.1
gptkbp:encodedBy	gptkb:MTOR_gene
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	regulation of cell proliferation regulation of cell survival regulation of autophagy regulation of cell growth regulation of cell motility regulation of protein synthesis
https://www.w3.org/2000/01/rdf-schema#label	mTOR (mechanistic target of rapamycin)
gptkbp:inhibitedBy	gptkb:everolimus gptkb:rapamycin gptkb:sirolimus gptkb:temsirolimus
gptkbp:locatedIn	gptkb:nucleus gptkb:cytoplasm
gptkbp:locatedOnChromosome	gptkb:chromosome_1p36.2
gptkbp:OMIM	601231
gptkbp:relatedTo	gptkb:PI3K/AKT_pathway gptkb:AMPK_pathway gptkb:TSC1/TSC2_complex
gptkbp:UniProtID	gptkb:P42345
gptkbp:bfsParent	gptkb:PI3K-AKT_signaling_pathway
gptkbp:bfsLayer	6