|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
gptkb:phosphoinositide_3-kinase_(PI3K)_pathway
|
|
gptkbp:alsoKnownAs
|
gptkb:PKB
gptkb:RAC-alpha_serine/threonine-protein_kinase
|
|
gptkbp:discoveredBy
|
gptkb:Dario_Alessi
|
|
gptkbp:discoveredIn
|
1991
|
|
gptkbp:encodedBy
|
gptkb:AKT1
gptkb:AKT2
gptkb:AKT3
|
|
gptkbp:function
|
cell growth regulation
serine/threonine kinase activity
cell survival regulation
apoptosis inhibition
glucose metabolism regulation
|
|
gptkbp:inhibitedBy
|
gptkb:MK-2206
gptkb:wortmannin
gptkb:triciribine
|
|
gptkbp:involvedIn
|
gptkb:PI3K/AKT/mTOR_pathway
cell proliferation
angiogenesis
cancer progression
insulin signaling pathway
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:locatedOnChromosome
|
gptkb:14q32.33_(AKT1)
gptkb:19q13.1_(AKT2)
gptkb:1q44_(AKT3)
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
gptkb:diabetes
|
|
gptkbp:PDB
|
gptkb:1UNQ
|
|
gptkbp:phosphorylatedAt
|
Ser473
Thr308
|
|
gptkbp:proteinFamily
|
gptkb:AKT_family
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
gptkb:pleckstrin_homology_domain
kinase domain
regulatory domain
|
|
gptkbp:substrate
|
gptkb:GSK-3
gptkb:TSC2
gptkb:p21
gptkb:p27
gptkb:BAD_protein
gptkb:FOXO_transcription_factors
gptkb:MDM2
gptkb:mTOR
|
|
gptkbp:UniProtID
|
gptkb:P31749
|
|
gptkbp:bfsParent
|
gptkb:phosphoinositide_3-kinase/AKT_pathway
|
|
gptkbp:bfsLayer
|
6
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
AKT (protein kinase B)
|