PTEN (phosphatase and tensin homolog)

URI: https://gptkb.org/entity/PTEN_(phosphatase_and_tensin_homolog)
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alias gptkb:MMAC1
gptkb:TEP1
gptkbp:associatedWith gptkb:cancer
gptkb:endometrial_cancer
gptkb:glioblastoma
melanoma
prostate cancer
gptkbp:discoveredBy gptkb:Peter_C._Steck
gptkbp:discoveredIn 1997
gptkbp:encodedBy gptkb:PTEN_gene
gptkbp:Entrez_Gene_ID 5728
gptkbp:enzymeCommissionNumber 3.1.3.67
gptkbp:expressedIn many human tissues
gptkbp:function tumor suppressor
phosphatase activity
gptkbp:HGNC_ID 9588
https://www.w3.org/2000/01/rdf-schema#label PTEN (phosphatase and tensin homolog)
gptkbp:inhibitedBy cell proliferation
cell survival
cell migration
cell invasion
gptkbp:locatedOnChromosome gptkb:10q23.3
gptkb:chromosome_10
gptkbp:lossOfFunctionLeadsTo tumorigenesis
overactivation of PI3K/AKT pathway
gptkbp:molecularWeight 47 kDa
gptkbp:mutationAssociatedWith gptkb:Bannayan–Riley–Ruvalcaba_syndrome
gptkb:cancer
gptkb:Cowden_syndrome
gptkbp:OMIM 601728
gptkbp:orthologInMouse Pten
gptkbp:PDB gptkb:1D5R
gptkbp:phosphataseType dual-specificity phosphatase
gptkbp:regulates gptkb:PI3K/AKT_signaling_pathway
apoptosis
DNA repair
angiogenesis
cell growth
cell migration
cell cycle
genomic stability
gptkbp:subcellularLocation gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
gptkbp:substrate gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkbp:UniProtID gptkb:P60484
gptkbp:bfsParent gptkb:AKT_signaling_pathway
gptkbp:bfsLayer 5