PTEN (phosphatase and tensin homolog)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene
gptkbp:alias	gptkb:MMAC1 gptkb:TEP1
gptkbp:associatedWith	gptkb:cancer gptkb:endometrial_cancer gptkb:glioblastoma gptkb:melanoma prostate cancer
gptkbp:discoveredBy	gptkb:Peter_C._Steck
gptkbp:discoveredIn	1997
gptkbp:encodedBy	gptkb:PTEN_gene
gptkbp:Entrez_Gene_ID	5728
gptkbp:enzymeCommissionNumber	3.1.3.67
gptkbp:expressedIn	many human tissues
gptkbp:function	gptkb:tumor_suppressor phosphatase activity
gptkbp:HGNC_ID	9588
gptkbp:inhibitedBy	cell proliferation cell survival cell migration cell invasion
gptkbp:locatedOnChromosome	gptkb:10q23.3 gptkb:chromosome_10
gptkbp:lossOfFunctionLeadsTo	tumorigenesis overactivation of PI3K/AKT pathway
gptkbp:molecularWeight	47 kDa
gptkbp:mutationAssociatedWith	gptkb:Bannayan–Riley–Ruvalcaba_syndrome gptkb:cancer gptkb:Cowden_syndrome
gptkbp:OMIM	601728
gptkbp:orthologInMouse	Pten
gptkbp:PDB	gptkb:1D5R
gptkbp:phosphataseType	dual-specificity phosphatase
gptkbp:regulates	gptkb:PI3K/AKT_signaling_pathway apoptosis DNA repair angiogenesis cell growth cell migration cell cycle genomic stability
gptkbp:subcellularLocation	gptkb:cell_membrane gptkb:nucleus gptkb:cytoplasm
gptkbp:substrate	gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkbp:UniProtID	gptkb:P60484
gptkbp:bfsParent	gptkb:PI3K-AKT_signaling_pathway
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	PTEN (phosphatase and tensin homolog)