|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:CDKN1A
gptkb:cyclin-dependent_kinase_inhibitor_1
|
|
gptkbp:amendedBy
|
phosphorylation
ubiquitination
|
|
gptkbp:encodedBy
|
gptkb:CDKN1A_gene
|
|
gptkbp:Entrez_Gene_ID
|
1026
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cell cycle regulation
inhibits cyclin-dependent kinases
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p21Cip1
|
|
gptkbp:inducedBy
|
gptkb:p53
|
|
gptkbp:interactsWith
|
gptkb:cyclin_D
gptkb:CDK2
gptkb:CDK4
gptkb:PCNA
gptkb:cyclin_E
|
|
gptkbp:involvedIn
|
apoptosis
cellular senescence
DNA damage response
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:6p21.2
|
|
gptkbp:molecularWeight
|
21 kDa
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:regulates
|
G1 phase of cell cycle
S phase of cell cycle
|
|
gptkbp:roleInCancer
|
tumor suppressor
can be downregulated in some cancers
can be overexpressed in some cancers
|
|
gptkbp:UniProtID
|
gptkb:P38936
|
|
gptkbp:bfsParent
|
gptkb:PI3K-AKT_signaling_pathway
|
|
gptkbp:bfsLayer
|
6
|