PI3K (phosphoinositide 3-kinase)

URI: https://gptkb.org/entity/PI3K_(phosphoinositide_3-kinase)
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:activatedBy gptkb:G_protein-coupled_receptors
gptkb:receptor_tyrosine_kinases
gptkbp:alternativeName gptkb:protein
PI3-kinase
gptkbp:catalyzes phosphorylation of phosphoinositides
gptkbp:discoveredBy gptkb:Lewis_Cantley
gptkbp:discoveredIn 1980s
gptkbp:downstreamOf gptkb:insulin_receptor
gptkb:AKT
gptkb:mTOR
EGF receptor
PDGF receptor
gptkbp:EC_number 2.7.1.153
gptkbp:encodedBy PIK3CA gene (for p110α)
PIK3CB gene (for p110β)
PIK3CD gene (for p110δ)
PIK3CG gene (for p110γ)
gptkbp:foundIn eukaryotes
https://www.w3.org/2000/01/rdf-schema#label PI3K (phosphoinositide 3-kinase)
gptkbp:inhibitedBy gptkb:LY294002
gptkb:wortmannin
gptkbp:involvedIn cell differentiation
cell proliferation
cell survival
cell growth
intracellular signaling
gptkbp:involves gptkb:cancer
gptkb:diabetes
inflammatory diseases
gptkbp:mayInclude gptkb:Class_III_PI3K
gptkb:Class_II_PI3K
gptkb:Class_I_PI3K
gptkbp:product gptkb:phosphatidylinositol_(3,4,5)-trisphosphate_(PIP3)
gptkbp:subunit p110 catalytic subunit
p85 regulatory subunit
gptkbp:target PI3K inhibitors
anticancer drugs
gptkbp:bfsParent gptkb:AKT_signaling_pathway
gptkbp:bfsLayer 5