|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:chronic_myelomonocytic_leukemia
gptkb:dermatofibrosarcoma_protuberans
gptkb:infantile_myofibromatosis
myeloproliferative neoplasms
|
|
gptkbp:discoveredBy
|
Yarden et al.
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:encodes
|
PDGFRβ protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000113721
5159
|
|
gptkbp:expressedIn
|
fibroblasts
pericytes
vascular smooth muscle cells
mesenchymal cells
|
|
gptkbp:fullName
|
gptkb:platelet-derived_growth_factor_receptor_beta
|
|
gptkbp:function
|
angiogenesis
cell differentiation regulation
cell proliferation regulation
receptor tyrosine kinase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
8804
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDGFRB gene
|
|
gptkbp:interactsWith
|
gptkb:PIK3R1
gptkb:SRC
gptkb:PLCγ1
gptkb:GRB2
gptkb:PDGFA
gptkb:PDGFB
gptkb:SH2B2
gptkb:STAT3
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q32
|
|
gptkbp:mutationAssociatedWith
|
oncogenic transformation
|
|
gptkbp:OMIM
|
173410
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Pdgfrb
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Ras_signaling_pathway
|
|
gptkbp:product
|
gptkb:PDGFRβ
|
|
gptkbp:recipient
|
cell surface receptor
|
|
gptkbp:targetOfDrug
|
gptkb:dasatinib
gptkb:sorafenib
gptkb:imatinib
gptkb:pazopanib
gptkb:regorafenib
gptkb:sunitinib
gptkb:crenolanib
|
|
gptkbp:UniProtID
|
gptkb:P09619
|
|
gptkbp:bfsParent
|
gptkb:PDGFRβ
gptkb:PDGFRA_gene
gptkb:CD140b
gptkb:Platelet-derived_growth_factor_receptor
gptkb:PDGF_receptor_beta
|
|
gptkbp:bfsLayer
|
7
|